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Publication: Dissociation of the N–Cα Bond and Competitive Formation of the [zn – H]●+ and [cn + 2H]+ Product Ions in Radical Peptide Ions Containing Tyrosine and Tryptophan: The Influence of Proton Affinities on Product Formation

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Title Dissociation of the N–Cα Bond and Competitive Formation of the [zn – H]●+ and [cn + 2H]+ Product Ions in Radical Peptide Ions Containing Tyrosine and Tryptophan: The Influence of Proton Affinities on Product Formation
Authors/Editors* Chi-Kit Siu, Yuyong Ke, Galina Orlova, Alan C. Hopkinson, and K. W. Michael Siu
Where published* Journal of the American Society for Mass Spectrometry
How published* Journal
Year* 2008
Volume 19
Number
Pages 1799-1807
Publisher
Keywords
Link http://dx.doi.org/10.1016/j.jasms.2008.09.026
Abstract
Dissociations at the N–C bond of tryptophan and tyrosine residues are the prevalent pathways in the fragmentations of radical cations of tripeptides that contain such as residues. This process involves a proton transfer from the -carbon of the tryptophan or tyrosine residue to the carbonyl oxygen of the amide group, followed by cleavage of the N–C bond, generating low-lying proton-bound dimers that dissociate to give each an ionic and a neutral product. Formation of the [zn – H]●+ or [cn + 2H]+ ion is a competition between the two incipient fragments for the proton in a dissociating proton-bound dimer.
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