Publication: Atomic determinants of state-dependent block of sodium channels by charged local anesthetics and benzocaine
All || By Area || By Year| Title | Atomic determinants of state-dependent block of sodium channels by charged local anesthetics and benzocaine | Authors/Editors* | Tikhonov DB, Bruhova I, Zhorov BS |
|---|---|
| Where published* | FEBS LETTERS |
| How published* | Journal |
| Year* | 2006 |
| Volume | 580 |
| Number | 26 |
| Pages | 6027-32 |
| Publisher | |
| Keywords | |
| Link | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17070808&query_hl=1&itool=pubmed_docsum |
| Abstract |
Molecular modeling predicts that a local anesthetic (LA) lidocaine binds to the resting and open Na(v)1.5 in different modes, interacting with LA-sensing residues known from experiments. Besides the major pathway via the open activation gate, LAs can reach the inner pore via a |
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