Publication: A lab-on-CD prototype for high-speed blood separation

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Title	A lab-on-CD prototype for high-speed blood separation
Authors/Editors*	A3. Jinlong Zhang, Qiuquan Guo, Mei Liu and Jun Yang
Where published*	Journal of Micromech. and Microeng
How published*	Journal
Year*	2008
Volume	18
Number
Pages	125025
Publisher
Keywords
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Abstract	Blood separation is the first step for subsequent blood tests in clinical diagnosis. Lab-on-a-chip technology provides an automatic, cost-effective and fast solution for a wide variety of blood analyses. The objective of this work is to design a new Lab-on-CD microstructure capable of separating blood cells from the whole blood into different reservoirs directly. A CD platform including a microchannel network consisting of a straight main microchannel, a curved microchannel and a branching microchannel has been proposed. The merits of this design are its simple structure, less operating time and high separation efficiency because it utilizes multiple separation mechanisms to optimize the performance, for instance, two centrifugal forces and Coriolis force. One centrifugal force is due to the system rotation; the other centrifugal force is due to the curvature of the specifically designed curved channel. In this work, systematical evaluation on functionality and performance of such design has been done. 99% separation efficiency is achieved for diluted blood of 6% hematocrit.