Publication: Potassium, sodium, calcium and glutamate-gated channels: pore architecture and ligand action

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Title	Potassium, sodium, calcium and glutamate-gated channels: pore architecture and ligand action
Authors/Editors*	Zhorov BS, Tikhonov DB
Where published*	J Neurochem
How published*	Journal
Year*	2004
Volume	88
Number	4
Pages	782-799
Publisher
Keywords
Link	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14756799&query_hl=1&itool=pubmed_docsum
Abstract	In the last decade, the idea of common organization of certain ion channel families exhibiting diverse physiological and pharmacological properties has received strong experimental support. Transmembrane topologies and patterns of the pore-facing residues are conserved in P-loop channels that include high-selective cation channels and certain ligand-gated channels. X-ray structures of bacterial K+ channels, KcsA, MthK and KvAP, help to understand structure-function relationships of other P-loop channels. Data on binding sites and mechanisms of action of ligands of K+, Na+, Ca2+ and glutamate gated ion channels are considered in view of their possible structural similarity to the bacterial K+ channels. Emphasized are structural determinants of ligand-receptor interactions within the channels and mechanisms of state-dependent action of the ligands.